Drug interactions
Bendroflumethiazide + Metformin-repaglinide
Severity: Minor
Bendroflumethiazide and Metformin-repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose, particularly at higher doses, and may reduce the effect of antidiabetic drugs. Glycemic control may worsen.
What this interaction means in plain words
Bendroflumethiazide and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Thiazides cause hypokalemia and reduced insulin secretion and sensitivity, opposing glucose-lowering drugs.
What to do
Monitor blood glucose after starting or changing thiazide dose. Adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Frequently asked questions
Can I take Bendroflumethiazide with Metformin-repaglinide?
MediHelp rates the interaction as minor. Bendroflumethiazide and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics can raise blood glucose, particularly at higher doses, and may reduce the effect of antidiabetic drugs. Glycemic control may worsen.
How serious is the interaction between Bendroflumethiazide and Metformin-repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or changing thiazide dose. Adjust antidiabetic therapy if control worsens.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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