Drug interactions
Bendroflumethiazide + Nateglinide
Severity: Minor
Bendroflumethiazide and Nateglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and reduce insulin secretion, which may weaken the glycemic control provided by nateglinide. The effect is usually modest and dose-related.
What this interaction means in plain words
Bendroflumethiazide and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic antagonism: thiazide-induced hypokalemia and reduced insulin release and sensitivity raise blood glucose.
What to do
Monitor blood glucose and HbA1c when a thiazide is started or its dose increased, and keep potassium in the normal range; adjust the antidiabetic therapy as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Bendroflumethiazide with Nateglinide?
MediHelp rates the interaction as minor. Bendroflumethiazide and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics can raise blood glucose and reduce insulin secretion, which may weaken the glycemic control provided by nateglinide. The effect is usually modest and dose-related.
How serious is the interaction between Bendroflumethiazide and Nateglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when a thiazide is started or its dose increased, and keep potassium in the normal range; adjust the antidiabetic therapy as needed.
What other medicines interact with Nateglinide?
MediHelp also lists interactions of Nateglinide with, for example, Albiglutide, Alogliptin-metformin, Alogliptin-pioglitazone. The full list is on the Nateglinide page.
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