Drug interactions
Amiodarone + Nateglinide
Severity: Moderate
Amiodarone and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone inhibits CYP2C9, which is the main pathway for nateglinide metabolism. Exposure may rise, increasing the risk of hypoglycemia.
What this interaction means in plain words
Amiodarone and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Nateglinide belongs to Endocrine.
Why it happens
CYP2C9 inhibition by amiodarone reduces nateglinide clearance.
What to do
Monitor blood glucose when starting or stopping amiodarone and advise patients on hypoglycemia symptoms. Lower the nateglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amobarbital + Nateglinide Moderate
Frequently asked questions
Can I take Amiodarone with Nateglinide?
MediHelp rates the interaction as moderate. Amiodarone and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone inhibits CYP2C9, which is the main pathway for nateglinide metabolism. Exposure may rise, increasing the risk of hypoglycemia.
How serious is the interaction between Amiodarone and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping amiodarone and advise patients on hypoglycemia symptoms. Lower the nateglinide dose if hypoglycemia occurs.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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