Drug interactions
Bendroflumethiazide + Sacubitril-valsartan
Severity: Moderate
Bendroflumethiazide and Sacubitril-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides lower potassium while valsartan raises it, so the combination often balances potassium but adds to blood pressure lowering. Hypotension, volume depletion and renal function changes can occur.
What this interaction means in plain words
Bendroflumethiazide and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive blood pressure lowering and volume depletion, with opposing effects on potassium excretion.
What to do
Monitor blood pressure, renal function and electrolytes after initiation or dose changes. Adjust the diuretic dose if hypotension or volume depletion develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Frequently asked questions
Can I take Bendroflumethiazide with Sacubitril-valsartan?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides lower potassium while valsartan raises it, so the combination often balances potassium but adds to blood pressure lowering. Hypotension, volume depletion and renal function changes can occur.
How serious is the interaction between Bendroflumethiazide and Sacubitril-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes after initiation or dose changes. Adjust the diuretic dose if hypotension or volume depletion develops.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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