Drug interactions
Bendroflumethiazide + Salmeterol
Severity: Moderate
Bendroflumethiazide and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can lower serum potassium, and combining them may produce clinically important hypokalemia. Low potassium raises the risk of cardiac arrhythmias, especially in patients with heart disease, hypoxia or those taking digoxin or QT-prolonging drugs.
What this interaction means in plain words
Bendroflumethiazide and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia from beta-2 stimulated intracellular potassium shift and thiazide-induced renal potassium loss.
What to do
Monitor serum potassium, particularly at the start of therapy or with high salmeterol doses. Replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Bendroflumethiazide with Salmeterol?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can lower serum potassium, and combining them may produce clinically important hypokalemia. Low potassium raises the risk of cardiac arrhythmias, especially in patients with heart disease, hypoxia or those taking digoxin or QT-prolonging drugs.
How serious is the interaction between Bendroflumethiazide and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, particularly at the start of therapy or with high salmeterol doses. Replace potassium as needed.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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