Drug interactions
Bendroflumethiazide + Tolvaptan
Severity: Moderate
Bendroflumethiazide and Tolvaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs promote renal fluid loss, and thiazides additionally cause hypokalemia and hyponatremia, so the combination can add to volume depletion, hypotension and electrolyte disturbance. Rapid correction of serum sodium with tolvaptan also needs careful control.
What this interaction means in plain words
Bendroflumethiazide and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive diuretic and aquaretic effects, with thiazide-induced electrolyte loss.
What to do
Monitor serum sodium, potassium, volume status and blood pressure closely, especially at initiation. Correct hypokalemia and watch for overly rapid sodium rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Bendroflumethiazide with Tolvaptan?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs promote renal fluid loss, and thiazides additionally cause hypokalemia and hyponatremia, so the combination can add to volume depletion, hypotension and electrolyte disturbance. Rapid correction of serum sodium with tolvaptan also needs careful control.
How serious is the interaction between Bendroflumethiazide and Tolvaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium, potassium, volume status and blood pressure closely, especially at initiation. Correct hypokalemia and watch for overly rapid sodium rise.
What other medicines interact with Tolvaptan?
MediHelp also lists interactions of Tolvaptan with, for example, Atazanavir, Ceritinib, Cobicistat. The full list is on the Tolvaptan page.
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