Drug interactions
Bendroflumethiazide + Triamterene
Severity: Minor
Bendroflumethiazide and Triamterene: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides cause potassium loss while triamterene retains it, so the combination is used deliberately to keep potassium stable. Potassium may still become too high or too low, particularly in renal impairment, so periodic checks are warranted.
What this interaction means in plain words
Bendroflumethiazide and Triamterene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing renal potassium handling: thiazide-induced kaliuresis versus ENaC blockade by triamterene.
What to do
Monitor serum potassium and sodium periodically, especially after initiation and in renal impairment. Avoid additional potassium supplements.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Bendroflumethiazide with Triamterene?
MediHelp rates the interaction as minor. Bendroflumethiazide and Triamterene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazides cause potassium loss while triamterene retains it, so the combination is used deliberately to keep potassium stable. Potassium may still become too high or too low, particularly in renal impairment, so periodic checks are warranted.
How serious is the interaction between Bendroflumethiazide and Triamterene?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and sodium periodically, especially after initiation and in renal impairment. Avoid additional potassium supplements.
What other medicines interact with Triamterene?
MediHelp also lists interactions of Triamterene with, for example, Amiloride, Eplerenone, Potassium citrate / citric acid. The full list is on the Triamterene page.
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