Drug interactions
Bendroflumethiazide + Valsartan
Severity: Minor
Bendroflumethiazide and Valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan and thiazide diuretics are commonly combined for additive blood pressure lowering. Valsartan tends to counteract thiazide-induced hypokalemia. Volume depletion can cause hypotension or renal function change.
What this interaction means in plain words
Bendroflumethiazide and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Complementary antihypertensive actions, with ARB-induced potassium retention offsetting thiazide potassium loss.
What to do
Monitor blood pressure, electrolytes and renal function after starting or changing doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Bendroflumethiazide with Valsartan?
MediHelp rates the interaction as minor. Bendroflumethiazide and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valsartan and thiazide diuretics are commonly combined for additive blood pressure lowering. Valsartan tends to counteract thiazide-induced hypokalemia. Volume depletion can cause hypotension or renal function change.
How serious is the interaction between Bendroflumethiazide and Valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, electrolytes and renal function after starting or changing doses.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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