Drug interactions
Benperidol + Chloral hydrate
Severity: Moderate
Benperidol and Chloral hydrate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benperidol is a potent butyrophenone antipsychotic with sedative properties, and chloral hydrate adds further CNS depression. The combination can cause excessive drowsiness, hypotension and impaired coordination.
What this interaction means in plain words
Benperidol and Chloral hydrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from the antipsychotic and the sedative-hypnotic.
What to do
Use the lowest effective doses and monitor sedation and blood pressure. Avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Frequently asked questions
Can I take Benperidol with Chloral hydrate?
MediHelp rates the interaction as moderate. Benperidol and Chloral hydrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benperidol is a potent butyrophenone antipsychotic with sedative properties, and chloral hydrate adds further CNS depression. The combination can cause excessive drowsiness, hypotension and impaired coordination.
How serious is the interaction between Benperidol and Chloral hydrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and blood pressure. Avoid driving and alcohol.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
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