Drug interactions
Benperidol + Clonazepam
Severity: Moderate
Benperidol and Clonazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benperidol is a potent antipsychotic with sedative properties, and with clonazepam it may increase drowsiness and impair alertness. Hypotension and respiratory depression are possible, particularly at higher doses or in frail patients.
What this interaction means in plain words
Benperidol and Clonazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from GABA-A potentiation and dopamine antagonism.
What to do
Use the lowest effective doses and monitor sedation, blood pressure and respiration, especially when doses are increased. Counsel on avoiding driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Frequently asked questions
Can I take Benperidol with Clonazepam?
MediHelp rates the interaction as moderate. Benperidol and Clonazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benperidol is a potent antipsychotic with sedative properties, and with clonazepam it may increase drowsiness and impair alertness. Hypotension and respiratory depression are possible, particularly at higher doses or in frail patients.
How serious is the interaction between Benperidol and Clonazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation, blood pressure and respiration, especially when doses are increased. Counsel on avoiding driving.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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