Drug interactions
Benperidol + Clozapine
Severity: Moderate
Benperidol and Clozapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two antipsychotics increases the risk of sedation, hypotension, extrapyramidal symptoms and neuroleptic malignant syndrome. Benperidol is a high-potency butyrophenone with substantial D2 blockade.
What this interaction means in plain words
Benperidol and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive dopamine D2 antagonism and CNS depression.
What to do
Avoid unnecessary antipsychotic polypharmacy and use the lowest effective doses. Monitor for movement disorders, sedation, fever and rigidity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Benperidol with Clozapine?
MediHelp rates the interaction as moderate. Benperidol and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining two antipsychotics increases the risk of sedation, hypotension, extrapyramidal symptoms and neuroleptic malignant syndrome. Benperidol is a high-potency butyrophenone with substantial D2 blockade.
How serious is the interaction between Benperidol and Clozapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary antipsychotic polypharmacy and use the lowest effective doses. Monitor for movement disorders, sedation, fever and rigidity.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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