Drug interactions
Benperidol + Codeine
Severity: Moderate
Benperidol and Codeine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benperidol is a butyrophenone antipsychotic with sedative and hypotensive properties. Combined with codeine it may cause additive sedation, respiratory depression and hypotension.
What this interaction means in plain words
Benperidol and Codeine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and hypotension from opioid agonism and dopamine and adrenergic receptor blockade.
What to do
Monitor sedation, blood pressure and respiratory rate, and start with reduced doses of each agent. Counsel patients about impaired alertness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Codeine
- Alvimopan + Codeine Contraindicated
- Codeine + Isocarboxazid Contraindicated
- Codeine + Olanzapine / samidorphan Contraindicated
- Codeine + Phenelzine Contraindicated
- Codeine + Tranylcypromine Contraindicated
- Alfentanil + Codeine Major
Frequently asked questions
Can I take Benperidol with Codeine?
MediHelp rates the interaction as moderate. Benperidol and Codeine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benperidol is a butyrophenone antipsychotic with sedative and hypotensive properties. Combined with codeine it may cause additive sedation, respiratory depression and hypotension.
How serious is the interaction between Benperidol and Codeine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and respiratory rate, and start with reduced doses of each agent. Counsel patients about impaired alertness.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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