Drug interactions
Benperidol + Cyclobenzaprine
Severity: Moderate
Benperidol and Cyclobenzaprine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and have anticholinergic activity, so combined use increases drowsiness, confusion and antimuscarinic effects. Cyclobenzaprine is structurally related to tricyclic antidepressants and may also add to QT or arrhythmia risk with antipsychotics.
What this interaction means in plain words
Benperidol and Cyclobenzaprine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and antimuscarinic effects, with possible additive cardiac conduction effects.
What to do
Monitor for oversedation and anticholinergic toxicity, and consider an ECG in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Benperidol with Cyclobenzaprine?
MediHelp rates the interaction as moderate. Benperidol and Cyclobenzaprine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and have anticholinergic activity, so combined use increases drowsiness, confusion and antimuscarinic effects. Cyclobenzaprine is structurally related to tricyclic antidepressants and may also add to QT or arrhythmia risk with antipsychotics.
How serious is the interaction between Benperidol and Cyclobenzaprine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and anticholinergic toxicity, and consider an ECG in patients with cardiac risk factors.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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