Drug interactions
Benperidol + Cyproheptadine
Severity: Moderate
Benperidol and Cyproheptadine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benperidol is a potent butyrophenone antipsychotic that causes sedation, and cyproheptadine adds further CNS depression. The combination can cause excess drowsiness and anticholinergic effects.
What this interaction means in plain words
Benperidol and Cyproheptadine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and antihistaminic and anticholinergic effects.
What to do
Monitor for sedation, confusion and anticholinergic effects, and reduce the dose of one drug if these occur. Counsel patients on driving and operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Frequently asked questions
Can I take Benperidol with Cyproheptadine?
MediHelp rates the interaction as moderate. Benperidol and Cyproheptadine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benperidol is a potent butyrophenone antipsychotic that causes sedation, and cyproheptadine adds further CNS depression. The combination can cause excess drowsiness and anticholinergic effects.
How serious is the interaction between Benperidol and Cyproheptadine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, confusion and anticholinergic effects, and reduce the dose of one drug if these occur. Counsel patients on driving and operating machinery.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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