Drug interactions
Benperidol + Diazepam
Severity: Moderate
Benperidol and Diazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benperidol is a potent butyrophenone antipsychotic, and combination with diazepam may increase sedation, hypotension and psychomotor impairment. The effect is usually manageable with dose adjustment.
What this interaction means in plain words
Benperidol and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from GABA-A potentiation and antipsychotic receptor blockade.
What to do
Monitor sedation and blood pressure, particularly when starting or increasing doses. Use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Frequently asked questions
Can I take Benperidol with Diazepam?
MediHelp rates the interaction as moderate. Benperidol and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benperidol is a potent butyrophenone antipsychotic, and combination with diazepam may increase sedation, hypotension and psychomotor impairment. The effect is usually manageable with dose adjustment.
How serious is the interaction between Benperidol and Diazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure, particularly when starting or increasing doses. Use the lowest effective doses.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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