Drug interactions
Benperidol + Diphenoxylate-atropine
Severity: Moderate
Benperidol and Diphenoxylate-atropine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benperidol is a sedating butyrophenone antipsychotic, and combined use with diphenoxylate-atropine may increase drowsiness. Atropine may add anticholinergic effects, and oral anticholinergics may slow gut absorption of antipsychotics.
What this interaction means in plain words
Benperidol and Diphenoxylate-atropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and antimuscarinic effects, with possible reduced oral absorption from slowed gastric motility.
What to do
Monitor for sedation, constipation, urinary retention and loss of antipsychotic effect. Limit the duration of antidiarrheal use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Frequently asked questions
Can I take Benperidol with Diphenoxylate-atropine?
MediHelp rates the interaction as moderate. Benperidol and Diphenoxylate-atropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benperidol is a sedating butyrophenone antipsychotic, and combined use with diphenoxylate-atropine may increase drowsiness. Atropine may add anticholinergic effects, and oral anticholinergics may slow gut absorption of antipsychotics.
How serious is the interaction between Benperidol and Diphenoxylate-atropine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, constipation, urinary retention and loss of antipsychotic effect. Limit the duration of antidiarrheal use.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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