Drug interactions
Benperidol + Doxylamine
Severity: Moderate
Benperidol and Doxylamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benperidol is a potent butyrophenone antipsychotic and doxylamine is a sedating anticholinergic antihistamine. Together they can increase drowsiness, anticholinergic effects and psychomotor impairment.
What this interaction means in plain words
Benperidol and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and anticholinergic effects through H1 and muscarinic blockade plus dopamine antagonism.
What to do
Monitor for sedation, confusion and anticholinergic symptoms. Avoid regular doxylamine use with benperidol, especially in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxylamine
Frequently asked questions
Can I take Benperidol with Doxylamine?
MediHelp rates the interaction as moderate. Benperidol and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benperidol is a potent butyrophenone antipsychotic and doxylamine is a sedating anticholinergic antihistamine. Together they can increase drowsiness, anticholinergic effects and psychomotor impairment.
How serious is the interaction between Benperidol and Doxylamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, confusion and anticholinergic symptoms. Avoid regular doxylamine use with benperidol, especially in older patients.
What other medicines interact with Doxylamine?
MediHelp also lists interactions of Doxylamine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Doxylamine page.
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