Drug interactions
Benperidol + Nortriptyline
Severity: Moderate
Benperidol and Nortriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, and the combination can increase drowsiness and impair psychomotor performance. Additive anticholinergic effects, hypotension and QT prolongation are also possible.
What this interaction means in plain words
Benperidol and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and overlapping antimuscarinic, alpha-blocking and cardiac conduction effects of the two drugs.
What to do
Monitor for excessive sedation, orthostatic hypotension and ECG changes, and start with low doses. Advise patients to avoid driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Benperidol with Nortriptyline?
MediHelp rates the interaction as moderate. Benperidol and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, and the combination can increase drowsiness and impair psychomotor performance. Additive anticholinergic effects, hypotension and QT prolongation are also possible.
How serious is the interaction between Benperidol and Nortriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, orthostatic hypotension and ECG changes, and start with low doses. Advise patients to avoid driving until the response is known.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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