Drug interactions
Benperidol + Salmeterol
Severity: Moderate
Benperidol and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salmeterol can cause QT prolongation and hypokalemia, and benperidol is an antipsychotic that may also prolong the QT interval. Together they could increase the risk of ventricular arrhythmias, especially with electrolyte disturbance or cardiac disease.
What this interaction means in plain words
Benperidol and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation potential, aggravated by beta-agonist-induced hypokalemia.
What to do
Check baseline ECG and potassium in patients with cardiac risk factors and correct electrolyte abnormalities. Monitor for palpitations or syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Benperidol and Salmeterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Benperidol with Salmeterol?
MediHelp rates the interaction as moderate. Benperidol and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salmeterol can cause QT prolongation and hypokalemia, and benperidol is an antipsychotic that may also prolong the QT interval. Together they could increase the risk of ventricular arrhythmias, especially with electrolyte disturbance or cardiac disease.
How serious is the interaction between Benperidol and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and potassium in patients with cardiac risk factors and correct electrolyte abnormalities. Monitor for palpitations or syncope.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
