Drug interactions
Benperidol + Scopolamine
Severity: Moderate
Benperidol and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Scopolamine and benperidol, a butyrophenone antipsychotic, both have anticholinergic effects, so combined use can increase dry mouth, constipation, urinary retention, blurred vision, confusion and heat intolerance. Anticholinergics may also reduce the antipsychotic effect and add to sedation, particularly in older adults.
What this interaction means in plain words
Benperidol and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic activity and CNS depression; anticholinergic effects on gut motility may slightly alter oral antipsychotic absorption.
What to do
Monitor for anticholinergic toxicity, delirium and sedation, especially in elderly patients, and use the lowest effective doses. Reassess antipsychotic response if scopolamine is started.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Scopolamine
Frequently asked questions
Can I take Benperidol with Scopolamine?
MediHelp rates the interaction as moderate. Benperidol and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Scopolamine and benperidol, a butyrophenone antipsychotic, both have anticholinergic effects, so combined use can increase dry mouth, constipation, urinary retention, blurred vision, confusion and heat intolerance. Anticholinergics may also reduce the antipsychotic effect and add to sedation, particularly in older adults.
How serious is the interaction between Benperidol and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, delirium and sedation, especially in elderly patients, and use the lowest effective doses. Reassess antipsychotic response if scopolamine is started.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
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