Drug interactions
Benperidol + Tolterodine
Severity: Moderate
Benperidol and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benperidol is a butyrophenone antipsychotic and may add to the anticholinergic effects of tolterodine. Both drugs can also prolong the QT interval, which may matter when other risk factors are present.
What this interaction means in plain words
Benperidol and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive anticholinergic effects and possible additive QT prolongation.
What to do
Monitor for anticholinergic effects and consider ECG monitoring in patients with cardiac risk factors or electrolyte disturbances. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Frequently asked questions
Can I take Benperidol with Tolterodine?
MediHelp rates the interaction as moderate. Benperidol and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benperidol is a butyrophenone antipsychotic and may add to the anticholinergic effects of tolterodine. Both drugs can also prolong the QT interval, which may matter when other risk factors are present.
How serious is the interaction between Benperidol and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and consider ECG monitoring in patients with cardiac risk factors or electrolyte disturbances. Correct potassium and magnesium abnormalities.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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