Drug interactions
Benzhydrocodone / acetaminophen + Brimonidine
Severity: Moderate
Benzhydrocodone / acetaminophen and Brimonidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzhydrocodone is an opioid prodrug of hydrocodone, and brimonidine can cause drowsiness. Combined use may increase sedation, and rarely respiratory depression, especially with systemic absorption of brimonidine or in young children.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Brimonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from opioid and alpha-2 agonist effects.
What to do
Monitor for sedation and respiratory depression, particularly at initiation or dose increases, and counsel patients not to drive if drowsy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Brimonidine?
MediHelp rates the interaction as moderate. Benzhydrocodone / acetaminophen and Brimonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzhydrocodone is an opioid prodrug of hydrocodone, and brimonidine can cause drowsiness. Combined use may increase sedation, and rarely respiratory depression, especially with systemic absorption of brimonidine or in young children.
How serious is the interaction between Benzhydrocodone / acetaminophen and Brimonidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression, particularly at initiation or dose increases, and counsel patients not to drive if drowsy.
What other medicines interact with Brimonidine?
MediHelp also lists interactions of Brimonidine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Brimonidine page.
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