Drug interactions
Benzhydrocodone / acetaminophen + Cariprazine
Severity: Major
Benzhydrocodone / acetaminophen and Cariprazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cariprazine combined with an opioid such as benzhydrocodone may cause additive sedation, respiratory depression, coma and death in severe cases. Impaired psychomotor performance is also expected.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Cariprazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from opioid agonism and antipsychotic sedation.
What to do
Reserve the combination for patients without adequate alternatives, limit dose and duration, and monitor for sedation and respiratory depression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cariprazine
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Cariprazine?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Cariprazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cariprazine combined with an opioid such as benzhydrocodone may cause additive sedation, respiratory depression, coma and death in severe cases. Impaired psychomotor performance is also expected.
How serious is the interaction between Benzhydrocodone / acetaminophen and Cariprazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve the combination for patients without adequate alternatives, limit dose and duration, and monitor for sedation and respiratory depression.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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