Drug interactions
Benzhydrocodone / acetaminophen + Dexamethasone-neomycin-polymyxin
Severity: Minor
Benzhydrocodone / acetaminophen and Dexamethasone-neomycin-polymyxin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone is a CYP3A4 inducer and may lower hydrocodone exposure. When the inducer is stopped, hydrocodone levels can rise and increase the risk of respiratory depression. With topical or ophthalmic dexamethasone the systemic effect is expected to be small.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Dexamethasone-neomycin-polymyxin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Dexamethasone induces CYP3A4, which increases hydrocodone clearance.
What to do
Monitor analgesic response and sedation if dexamethasone exposure is substantial, especially after stopping it; no routine adjustment is needed for topical use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Dexamethasone-neomycin-polymyxin?
MediHelp rates the interaction as minor. Benzhydrocodone / acetaminophen and Dexamethasone-neomycin-polymyxin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexamethasone is a CYP3A4 inducer and may lower hydrocodone exposure. When the inducer is stopped, hydrocodone levels can rise and increase the risk of respiratory depression. With topical or ophthalmic dexamethasone the systemic effect is expected to be small.
How serious is the interaction between Benzhydrocodone / acetaminophen and Dexamethasone-neomycin-polymyxin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic response and sedation if dexamethasone exposure is substantial, especially after stopping it; no routine adjustment is needed for topical use.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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