Drug interactions
Dexamethasone-neomycin-polymyxin + Lapatinib
Severity: Major
Dexamethasone-neomycin-polymyxin and Lapatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone induces CYP3A4 and may substantially reduce lapatinib exposure, risking loss of efficacy. Lapatinib may modestly raise dexamethasone exposure through CYP3A4 and P-glycoprotein inhibition.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Lapatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Lapatinib belongs to Oncology.
Why it happens
Dexamethasone induces CYP3A4 and increases lapatinib clearance, while lapatinib weakly inhibits CYP3A4 and P-glycoprotein.
What to do
Avoid prolonged systemic dexamethasone with lapatinib where possible, or consider a lapatinib dose increase per labeling for strong inducers. Monitor tumor response and corticosteroid effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
- Allogeneic cultured keratinocytes / fibroblasts in bovine collagen + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Lapatinib?
MediHelp rates the interaction as major. Dexamethasone-neomycin-polymyxin and Lapatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dexamethasone induces CYP3A4 and may substantially reduce lapatinib exposure, risking loss of efficacy. Lapatinib may modestly raise dexamethasone exposure through CYP3A4 and P-glycoprotein inhibition.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Lapatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged systemic dexamethasone with lapatinib where possible, or consider a lapatinib dose increase per labeling for strong inducers. Monitor tumor response and corticosteroid effects.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Levofloxacin, Mifepristone. The full list is on the Dexamethasone-neomycin-polymyxin page.
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