Drug interactions
Benzhydrocodone / acetaminophen + Dimenhydrinate
Severity: Moderate
Benzhydrocodone / acetaminophen and Dimenhydrinate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzhydrocodone is an opioid prodrug, and combining it with a sedating antihistamine increases drowsiness and may add to respiratory depression. The risk is higher in older or debilitated patients.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Dimenhydrinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression.
What to do
Use the lowest effective doses and monitor sedation and respiratory rate. Counsel patients to avoid alcohol and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dimenhydrinate
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Dimenhydrinate?
MediHelp rates the interaction as moderate. Benzhydrocodone / acetaminophen and Dimenhydrinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzhydrocodone is an opioid prodrug, and combining it with a sedating antihistamine increases drowsiness and may add to respiratory depression. The risk is higher in older or debilitated patients.
How serious is the interaction between Benzhydrocodone / acetaminophen and Dimenhydrinate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and respiratory rate. Counsel patients to avoid alcohol and driving.
What other medicines interact with Dimenhydrinate?
MediHelp also lists interactions of Dimenhydrinate with, for example, Belladonna and opium, Brexanolone, Calcium / magnesium / potassium / sodium oxybates. The full list is on the Dimenhydrinate page.
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