Drug interactions
Benzhydrocodone / acetaminophen + Frovatriptan
Severity: Moderate
Benzhydrocodone / acetaminophen and Frovatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzhydrocodone is a prodrug of hydrocodone, an opioid with weak serotonergic activity. Concurrent use with a triptan carries a theoretical risk of serotonin syndrome, which has been noted in labeling for opioids and triptans.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Frovatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic neurotransmission; the opioid effect is weak and the mechanism is not firmly established.
What to do
If coadministration is needed, observe the patient closely during initiation and dose changes for signs of serotonin syndrome. Stop treatment and give supportive care if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Frovatriptan?
MediHelp rates the interaction as moderate. Benzhydrocodone / acetaminophen and Frovatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzhydrocodone is a prodrug of hydrocodone, an opioid with weak serotonergic activity. Concurrent use with a triptan carries a theoretical risk of serotonin syndrome, which has been noted in labeling for opioids and triptans.
How serious is the interaction between Benzhydrocodone / acetaminophen and Frovatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If coadministration is needed, observe the patient closely during initiation and dose changes for signs of serotonin syndrome. Stop treatment and give supportive care if symptoms appear.
What other medicines interact with Frovatriptan?
MediHelp also lists interactions of Frovatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Frovatriptan page.
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