Drug interactions
Benzhydrocodone / acetaminophen + Isocarboxazid
Severity: Major
Benzhydrocodone / acetaminophen and Isocarboxazid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzhydrocodone is a prodrug of hydrocodone, and opioids with MAOIs can cause serotonin syndrome or opioid toxicity including respiratory depression and coma. Labeling advises against use with MAOIs or within 14 days of stopping.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Isocarboxazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
MAO inhibition may enhance serotonergic and opioid effects, with the exact mechanism not fully established.
What to do
Avoid combined use and allow 14 days after stopping isocarboxazid. Use a non-opioid analgesic or monitor closely if an opioid is unavoidable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Isocarboxazid?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Isocarboxazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benzhydrocodone is a prodrug of hydrocodone, and opioids with MAOIs can cause serotonin syndrome or opioid toxicity including respiratory depression and coma. Labeling advises against use with MAOIs or within 14 days of stopping.
How serious is the interaction between Benzhydrocodone / acetaminophen and Isocarboxazid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use and allow 14 days after stopping isocarboxazid. Use a non-opioid analgesic or monitor closely if an opioid is unavoidable.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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