Drug interactions
Benzhydrocodone / acetaminophen + Levocetirizine
Severity: Moderate
Benzhydrocodone / acetaminophen and Levocetirizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzhydrocodone is a prodrug of hydrocodone, an opioid, and sedating antihistamines can add to its CNS and respiratory depression. Excessive drowsiness and impaired psychomotor function may occur.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Levocetirizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression between an opioid and a sedating antihistamine.
What to do
Use the lowest effective opioid dose and monitor for sedation and respiratory depression; counsel on avoiding driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levocetirizine
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Levocetirizine?
MediHelp rates the interaction as moderate. Benzhydrocodone / acetaminophen and Levocetirizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzhydrocodone is a prodrug of hydrocodone, an opioid, and sedating antihistamines can add to its CNS and respiratory depression. Excessive drowsiness and impaired psychomotor function may occur.
How serious is the interaction between Benzhydrocodone / acetaminophen and Levocetirizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective opioid dose and monitor for sedation and respiratory depression; counsel on avoiding driving and alcohol.
What other medicines interact with Levocetirizine?
MediHelp also lists interactions of Levocetirizine with, for example, Acrivastine, Asenapine transdermal, Avapritinib. The full list is on the Levocetirizine page.
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