Drug interactions
Avapritinib + Levocetirizine
Severity: Moderate
Avapritinib and Levocetirizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects such as memory impairment and confusion, and levocetirizine may add to drowsiness. Combined use could worsen impaired alertness.
What this interaction means in plain words
Avapritinib and Levocetirizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Levocetirizine belongs to Respiratory.
Why it happens
Additive CNS effects (pharmacodynamic).
What to do
Monitor cognition and sedation; reassess the need for the antihistamine if CNS effects increase.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levocetirizine
- Acrivastine + Levocetirizine Moderate
- Asenapine transdermal + Levocetirizine Moderate
- Benzhydrocodone / acetaminophen + Levocetirizine Moderate
- Buprenorphine long-acting + Levocetirizine Moderate
- Buprenorphine subdermal implant + Levocetirizine Moderate
- Buprenorphine transdermal + Levocetirizine Moderate
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Levocetirizine?
MediHelp rates the interaction as moderate. Avapritinib and Levocetirizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects such as memory impairment and confusion, and levocetirizine may add to drowsiness. Combined use could worsen impaired alertness.
How serious is the interaction between Avapritinib and Levocetirizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cognition and sedation; reassess the need for the antihistamine if CNS effects increase.
What other medicines interact with Levocetirizine?
MediHelp also lists interactions of Levocetirizine with, for example, Acrivastine, Asenapine transdermal, Benzhydrocodone / acetaminophen. The full list is on the Levocetirizine page.
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