Drug interactions
Benzhydrocodone / acetaminophen + Lorlatinib
Severity: Moderate
Benzhydrocodone / acetaminophen and Lorlatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzhydrocodone is a prodrug of hydrocodone, which is metabolized by CYP3A4. Lorlatinib induction may lower hydrocodone levels and reduce analgesia, and withdrawal could occur in opioid-dependent patients.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 induction by lorlatinib increases hydrocodone metabolism to inactive norhydrocodone.
What to do
Monitor pain control and opioid withdrawal symptoms, and adjust the opioid dose as needed. If lorlatinib is stopped, watch for opioid toxicity as induction wanes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Lorlatinib?
MediHelp rates the interaction as moderate. Benzhydrocodone / acetaminophen and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzhydrocodone is a prodrug of hydrocodone, which is metabolized by CYP3A4. Lorlatinib induction may lower hydrocodone levels and reduce analgesia, and withdrawal could occur in opioid-dependent patients.
How serious is the interaction between Benzhydrocodone / acetaminophen and Lorlatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain control and opioid withdrawal symptoms, and adjust the opioid dose as needed. If lorlatinib is stopped, watch for opioid toxicity as induction wanes.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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