Drug interactions
Benzhydrocodone / acetaminophen + Methocarbamol
Severity: Major
Benzhydrocodone / acetaminophen and Methocarbamol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzhydrocodone is an opioid prodrug of hydrocodone, and methocarbamol is a sedating muscle relaxant. Together they can increase sedation and respiratory depression, with a risk of coma or death at high exposures.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Methocarbamol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression.
What to do
Reserve the combination for patients with inadequate alternatives, using the lowest doses for the shortest time. Monitor for sedation and respiratory depression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Methocarbamol
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Methocarbamol?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Methocarbamol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benzhydrocodone is an opioid prodrug of hydrocodone, and methocarbamol is a sedating muscle relaxant. Together they can increase sedation and respiratory depression, with a risk of coma or death at high exposures.
How serious is the interaction between Benzhydrocodone / acetaminophen and Methocarbamol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve the combination for patients with inadequate alternatives, using the lowest doses for the shortest time. Monitor for sedation and respiratory depression.
What other medicines interact with Methocarbamol?
MediHelp also lists interactions of Methocarbamol with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Methocarbamol page.
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