Drug interactions
Amobarbital + Methocarbamol
Severity: Major
Amobarbital and Methocarbamol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital is a barbiturate and methocarbamol is a CNS-depressant muscle relaxant. Together they can cause deep sedation, respiratory depression and impaired consciousness, especially at higher doses, with alcohol, or in older patients.
What this interaction means in plain words
Amobarbital and Methocarbamol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Methocarbamol belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression, with barbiturate potentiation of GABA-A activity.
What to do
Avoid the combination where possible, or use the lowest doses for the shortest time. Monitor level of consciousness and respiratory rate, and advise against alcohol.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Methocarbamol
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Methocarbamol?
MediHelp rates the interaction as major. Amobarbital and Methocarbamol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amobarbital is a barbiturate and methocarbamol is a CNS-depressant muscle relaxant. Together they can cause deep sedation, respiratory depression and impaired consciousness, especially at higher doses, with alcohol, or in older patients.
How serious is the interaction between Amobarbital and Methocarbamol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use the lowest doses for the shortest time. Monitor level of consciousness and respiratory rate, and advise against alcohol.
What other medicines interact with Methocarbamol?
MediHelp also lists interactions of Methocarbamol with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Methocarbamol page.
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