Drug interactions
Benzhydrocodone / acetaminophen + Rasagiline
Severity: Major
Benzhydrocodone / acetaminophen and Rasagiline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids combined with MAO inhibitors can cause serotonin syndrome or opioid toxicity with respiratory depression, hypotension and coma. Hydrocodone-type opioids are generally not recommended during or shortly after MAO inhibitor therapy.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Rasagiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Possible serotonergic potentiation and additive CNS depression with MAO inhibition.
What to do
Avoid the combination and for 14 days after rasagiline. If an opioid is urgently needed, use small test doses with careful titration and monitor blood pressure, mental status and respiration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Rasagiline?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Rasagiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids combined with MAO inhibitors can cause serotonin syndrome or opioid toxicity with respiratory depression, hypotension and coma. Hydrocodone-type opioids are generally not recommended during or shortly after MAO inhibitor therapy.
How serious is the interaction between Benzhydrocodone / acetaminophen and Rasagiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and for 14 days after rasagiline. If an opioid is urgently needed, use small test doses with careful titration and monitor blood pressure, mental status and respiration.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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