Drug interactions
Benzhydrocodone / acetaminophen + Rocuronium
Severity: Moderate
Benzhydrocodone / acetaminophen and Rocuronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The oral opioid adds respiratory depression and sedation to the paralysis produced by rocuronium. Rocuronium is used in controlled settings with ventilation, so the risk mainly arises where ventilation is not assured or recovery is incomplete.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Rocuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive respiratory compromise from central opioid depression and peripheral neuromuscular blockade.
What to do
Ensure ventilatory support and monitor oxygenation and train-of-four. After recovery, confirm full reversal of blockade before relying on oral opioid analgesia and observe for respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rocuronium
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Rocuronium?
MediHelp rates the interaction as moderate. Benzhydrocodone / acetaminophen and Rocuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The oral opioid adds respiratory depression and sedation to the paralysis produced by rocuronium. Rocuronium is used in controlled settings with ventilation, so the risk mainly arises where ventilation is not assured or recovery is incomplete.
How serious is the interaction between Benzhydrocodone / acetaminophen and Rocuronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure ventilatory support and monitor oxygenation and train-of-four. After recovery, confirm full reversal of blockade before relying on oral opioid analgesia and observe for respiratory depression.
What other medicines interact with Rocuronium?
MediHelp also lists interactions of Rocuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Rocuronium page.
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