Drug interactions
Fentanyl iontophoretic transdermal system + Scopolamine
Severity: Major
Fentanyl iontophoretic transdermal system and Scopolamine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fentanyl delivered by an iontophoretic system is a potent opioid with sedative and respiratory depressant effects. Scopolamine can add to drowsiness and cognitive impairment, increasing the risk of dangerous CNS depression.
What this interaction means in plain words
Fentanyl iontophoretic transdermal system and Scopolamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from opioid agonism and central antimuscarinic effects.
What to do
Avoid the combination where possible and choose a non-sedating alternative to scopolamine. If used together, monitor sedation and respiratory status closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Scopolamine
Frequently asked questions
Can I take Fentanyl iontophoretic transdermal system with Scopolamine?
MediHelp rates the interaction as major. Fentanyl iontophoretic transdermal system and Scopolamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fentanyl delivered by an iontophoretic system is a potent opioid with sedative and respiratory depressant effects. Scopolamine can add to drowsiness and cognitive impairment, increasing the risk of dangerous CNS depression.
How serious is the interaction between Fentanyl iontophoretic transdermal system and Scopolamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose a non-sedating alternative to scopolamine. If used together, monitor sedation and respiratory status closely.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
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