Drug interactions
benzodiazepines (e.g., lorazepam) + clozapine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Respiratory/circulatory collapse (rare) esp. on initiation.
Mechanism of action
Additive CNS/resp depression.
Clinical management
Use caution; avoid rapid dose escalation; monitor closely.
Drug reference
References
Frequently asked questions
Can I take benzodiazepines (e.g., lorazepam) with clozapine?
The interaction is rated: Major. Respiratory/circulatory collapse (rare) esp. on initiation.
How serious is the interaction between benzodiazepines (e.g., lorazepam) and clozapine?
The interaction is rated: Major. Evidence level: Moderate.
How is the interaction between benzodiazepines (e.g., lorazepam) and clozapine managed?
Use caution; avoid rapid dose escalation; monitor closely.
Why do benzodiazepines (e.g., lorazepam) and clozapine interact?
Additive CNS/resp depression.
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