Drug interactions
Benzphetamine + Clozapine
Severity: Moderate
Benzphetamine and Clozapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine is strongly sedating while benzphetamine is a sympathomimetic stimulant, so their effects on alertness oppose each other unpredictably. Benzphetamine may also add to tachycardia and blood pressure changes already seen with clozapine.
What this interaction means in plain words
Benzphetamine and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing pharmacodynamic CNS effects plus additive sympathomimetic and cardiovascular effects; no established pharmacokinetic mechanism.
What to do
Monitor heart rate, blood pressure and level of sedation when the two are used together. Reassess the need for the anorectic if tachycardia or agitation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Benzphetamine with Clozapine?
MediHelp rates the interaction as moderate. Benzphetamine and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine is strongly sedating while benzphetamine is a sympathomimetic stimulant, so their effects on alertness oppose each other unpredictably. Benzphetamine may also add to tachycardia and blood pressure changes already seen with clozapine.
How serious is the interaction between Benzphetamine and Clozapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and level of sedation when the two are used together. Reassess the need for the anorectic if tachycardia or agitation develops.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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