Drug interactions
Benzphetamine + Isocarboxazid
Severity: Contraindicated
Benzphetamine and Isocarboxazid: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzphetamine is a sympathomimetic, and with an MAOI it can provoke severe hypertension and hypertensive crisis. It is contraindicated during and shortly after MAOI therapy.
What this interaction means in plain words
Benzphetamine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
MAO inhibition leaves norepinephrine stores increased, and the amphetamine-like release of these stores causes an exaggerated pressor response.
What to do
Do not use together or within 14 days of stopping the MAOI. Choose non-pharmacologic or non-stimulant weight management options.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Benzphetamine with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Benzphetamine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Benzphetamine is a sympathomimetic, and with an MAOI it can provoke severe hypertension and hypertensive crisis. It is contraindicated during and shortly after MAOI therapy.
How serious is the interaction between Benzphetamine and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together or within 14 days of stopping the MAOI. Choose non-pharmacologic or non-stimulant weight management options.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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