Drug interactions
Benzphetamine + Linezolid
Severity: Contraindicated
Benzphetamine and Linezolid: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzphetamine is a sympathomimetic anorectic and linezolid inhibits MAO. The combination can cause an exaggerated release of catecholamines, leading to hypertensive crisis.
What this interaction means in plain words
Benzphetamine and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
MAO inhibition by linezolid potentiates catecholamine release from sympathomimetic amines.
What to do
Do not use together. Stop benzphetamine and use a non-sympathomimetic alternative antibiotic; if linezolid is vital, monitor blood pressure intensively.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Benzphetamine and Linezolid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
- Buspirone + Linezolid Contraindicated
Frequently asked questions
Can I take Benzphetamine with Linezolid?
MediHelp rates the interaction as contraindicated. Benzphetamine and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Benzphetamine is a sympathomimetic anorectic and linezolid inhibits MAO. The combination can cause an exaggerated release of catecholamines, leading to hypertensive crisis.
How serious is the interaction between Benzphetamine and Linezolid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Stop benzphetamine and use a non-sympathomimetic alternative antibiotic; if linezolid is vital, monitor blood pressure intensively.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Brimonidine. The full list is on the Linezolid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
