Drug interactions
Benzphetamine + Methadone
Severity: Minor
Benzphetamine and Methadone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzphetamine is a sympathomimetic stimulant that may partly offset opioid sedation but does not prevent respiratory depression. The combined effects on alertness and cardiovascular status are unpredictable.
What this interaction means in plain words
Benzphetamine and Methadone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing CNS effects of opioid agonism and sympathomimetic stimulation; the net effect is not well characterized.
What to do
Monitor sedation, heart rate and blood pressure. Do not use the stimulant to counteract opioid effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Frequently asked questions
Can I take Benzphetamine with Methadone?
MediHelp rates the interaction as minor. Benzphetamine and Methadone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Benzphetamine is a sympathomimetic stimulant that may partly offset opioid sedation but does not prevent respiratory depression. The combined effects on alertness and cardiovascular status are unpredictable.
How serious is the interaction between Benzphetamine and Methadone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, heart rate and blood pressure. Do not use the stimulant to counteract opioid effects.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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