Drug interactions
Benzphetamine + Salmeterol
Severity: Moderate
Benzphetamine and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzphetamine is a sympathomimetic anorectic, and with salmeterol it may add to increases in heart rate and blood pressure. Palpitations, tremor, and arrhythmias are possible, particularly in people with cardiovascular disease.
What this interaction means in plain words
Benzphetamine and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sympathomimetic effects via indirect catecholamine release and direct beta-2 agonism.
What to do
Monitor blood pressure and heart rate, and avoid the combination in patients with significant cardiovascular disease or uncontrolled hypertension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Benzphetamine with Salmeterol?
MediHelp rates the interaction as moderate. Benzphetamine and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzphetamine is a sympathomimetic anorectic, and with salmeterol it may add to increases in heart rate and blood pressure. Palpitations, tremor, and arrhythmias are possible, particularly in people with cardiovascular disease.
How serious is the interaction between Benzphetamine and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, and avoid the combination in patients with significant cardiovascular disease or uncontrolled hypertension.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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