Drug interactions
Benztropine + Imipramine
Severity: Moderate
Benztropine and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are strongly anticholinergic, so combined use can cause marked peripheral and central anticholinergic toxicity. Effects include urinary retention, constipation, hyperthermia, confusion and tachycardia, and are more likely in older adults.
What this interaction means in plain words
Benztropine and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benztropine belongs to Central Nervous System; Imipramine belongs to Central Nervous System.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Monitor for anticholinergic toxicity and cognitive effects. Use the lowest effective benztropine dose or consider alternatives to a tricyclic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Benztropine
- Benztropine + Memantine-donepezil Major
- Abobotulinumtoxina + Benztropine Moderate
- Amantadine + Benztropine Moderate
- Amitriptyline + Benztropine Moderate
- Amoxapine + Benztropine Moderate
- Atropine iv / + Benztropine Moderate
Frequently asked questions
Can I take Benztropine with Imipramine?
MediHelp rates the interaction as moderate. Benztropine and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are strongly anticholinergic, so combined use can cause marked peripheral and central anticholinergic toxicity. Effects include urinary retention, constipation, hyperthermia, confusion and tachycardia, and are more likely in older adults.
How serious is the interaction between Benztropine and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and cognitive effects. Use the lowest effective benztropine dose or consider alternatives to a tricyclic.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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