Drug interactions
Benztropine + Tolterodine
Severity: Moderate
Benztropine and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benztropine is a potent central and peripheral anticholinergic, and combining it with tolterodine markedly increases antimuscarinic burden. This may cause constipation, urinary retention, heat intolerance, confusion and tachycardia, particularly in older adults.
What this interaction means in plain words
Benztropine and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benztropine belongs to Central Nervous System; Tolterodine belongs to Genitourinary.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for cognitive impairment, urinary retention and ileus. Use the lowest effective doses and consider a non-anticholinergic bladder option.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Other interactions of Benztropine
- Benztropine + Memantine-donepezil Major
- Abobotulinumtoxina + Benztropine Moderate
- Amantadine + Benztropine Moderate
- Amitriptyline + Benztropine Moderate
- Amoxapine + Benztropine Moderate
- Atropine iv / + Benztropine Moderate
Frequently asked questions
Can I take Benztropine with Tolterodine?
MediHelp rates the interaction as moderate. Benztropine and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benztropine is a potent central and peripheral anticholinergic, and combining it with tolterodine markedly increases antimuscarinic burden. This may cause constipation, urinary retention, heat intolerance, confusion and tachycardia, particularly in older adults.
How serious is the interaction between Benztropine and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cognitive impairment, urinary retention and ileus. Use the lowest effective doses and consider a non-anticholinergic bladder option.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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