Drug interactions
Berotralstat + Dexamethasone-tobramycin
Severity: Minor
Berotralstat and Dexamethasone-tobramycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat inhibits P-glycoprotein and may raise exposure to dexamethasone, which is a P-gp substrate. Higher corticosteroid exposure could increase systemic steroid effects. The clinical significance with the ophthalmic combination is likely small.
What this interaction means in plain words
Berotralstat and Dexamethasone-tobramycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Berotralstat belongs to Miscellaneous; Dexamethasone-tobramycin belongs to Anti Bacterial.
Why it happens
Berotralstat inhibits intestinal and cellular P-glycoprotein efflux, reducing dexamethasone efflux.
What to do
No routine adjustment is needed; watch for corticosteroid adverse effects such as hyperglycemia or fluid retention if systemic dexamethasone is used at high doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Dexamethasone-tobramycin?
MediHelp rates the interaction as minor. Berotralstat and Dexamethasone-tobramycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Berotralstat inhibits P-glycoprotein and may raise exposure to dexamethasone, which is a P-gp substrate. Higher corticosteroid exposure could increase systemic steroid effects. The clinical significance with the ophthalmic combination is likely small.
How serious is the interaction between Berotralstat and Dexamethasone-tobramycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; watch for corticosteroid adverse effects such as hyperglycemia or fluid retention if systemic dexamethasone is used at high doses.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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