Drug interactions
Berotralstat + Etoposide
Severity: Moderate
Berotralstat and Etoposide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat inhibits P-glycoprotein, and etoposide is a P-gp substrate, so etoposide absorption and exposure may rise. This may increase myelosuppression and gastrointestinal toxicity.
What this interaction means in plain words
Berotralstat and Etoposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Berotralstat belongs to Miscellaneous; Etoposide belongs to Oncology.
Why it happens
Inhibition of P-gp-mediated efflux of etoposide by berotralstat.
What to do
Monitor blood counts and etoposide toxicity, and consider reducing the etoposide dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporine + Etoposide Major
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Etoposide?
MediHelp rates the interaction as moderate. Berotralstat and Etoposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Berotralstat inhibits P-glycoprotein, and etoposide is a P-gp substrate, so etoposide absorption and exposure may rise. This may increase myelosuppression and gastrointestinal toxicity.
How serious is the interaction between Berotralstat and Etoposide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and etoposide toxicity, and consider reducing the etoposide dose if toxicity appears.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporine. The full list is on the Etoposide page.
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