Drug interactions
Berotralstat + Hydrocortisone
Severity: Minor
Berotralstat and Hydrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat inhibits P-glycoprotein and may increase exposure to hydrocortisone, which is a P-gp substrate. Increased corticosteroid effect is possible but the clinical impact is likely modest.
What this interaction means in plain words
Berotralstat and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Berotralstat belongs to Miscellaneous; Hydrocortisone belongs to Endocrine.
Why it happens
Inhibition of intestinal and cellular P-glycoprotein efflux by berotralstat reduces hydrocortisone efflux and increases its absorption and exposure.
What to do
Monitor for signs of corticosteroid excess such as fluid retention, hyperglycemia and hypertension during long-term therapy. Reduce the hydrocortisone dose if adverse effects appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Hydrocortisone?
MediHelp rates the interaction as minor. Berotralstat and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Berotralstat inhibits P-glycoprotein and may increase exposure to hydrocortisone, which is a P-gp substrate. Increased corticosteroid effect is possible but the clinical impact is likely modest.
How serious is the interaction between Berotralstat and Hydrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of corticosteroid excess such as fluid retention, hyperglycemia and hypertension during long-term therapy. Reduce the hydrocortisone dose if adverse effects appear.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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