Drug interactions
Berotralstat + Methotrexate
Severity: Moderate
Berotralstat and Methotrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat inhibits P-glycoprotein and may raise methotrexate exposure. This could increase methotrexate toxicity such as cytopenias and mucositis.
What this interaction means in plain words
Berotralstat and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Berotralstat belongs to Miscellaneous; Methotrexate belongs to Oncology.
Why it happens
P-glycoprotein inhibition by berotralstat reduces methotrexate efflux and increases absorption.
What to do
Monitor blood counts, liver and renal function, and watch for methotrexate toxicity. Reduce the methotrexate dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Methotrexate?
MediHelp rates the interaction as moderate. Berotralstat and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Berotralstat inhibits P-glycoprotein and may raise methotrexate exposure. This could increase methotrexate toxicity such as cytopenias and mucositis.
How serious is the interaction between Berotralstat and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, liver and renal function, and watch for methotrexate toxicity. Reduce the methotrexate dose if needed.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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