Drug interactions
Berotralstat + Phenytoin
Severity: Moderate
Berotralstat and Phenytoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin induces P-glycoprotein and CYP3A4, and berotralstat is a substrate of P-gp and CYP3A4. Berotralstat exposure may be reduced, potentially lowering its effectiveness in preventing hereditary angioedema attacks.
What this interaction means in plain words
Berotralstat and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Berotralstat belongs to Miscellaneous; Phenytoin belongs to Central Nervous System.
Why it happens
Induction of P-glycoprotein and CYP3A4 by phenytoin increases efflux and metabolism of berotralstat.
What to do
Monitor for increased frequency of angioedema attacks. Consider an alternative anticonvulsant or prophylactic agent if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Phenytoin?
MediHelp rates the interaction as moderate. Berotralstat and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenytoin induces P-glycoprotein and CYP3A4, and berotralstat is a substrate of P-gp and CYP3A4. Berotralstat exposure may be reduced, potentially lowering its effectiveness in preventing hereditary angioedema attacks.
How serious is the interaction between Berotralstat and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased frequency of angioedema attacks. Consider an alternative anticonvulsant or prophylactic agent if control is lost.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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