Drug interactions
Berotralstat + Tenofovir disoproxil
Severity: Minor
Berotralstat and Tenofovir disoproxil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat inhibits P-glycoprotein and may raise concentrations of tenofovir disoproxil, which is a P-gp substrate at the gut. The expected increase is modest.
What this interaction means in plain words
Berotralstat and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Berotralstat inhibits intestinal P-gp, increasing tenofovir absorption.
What to do
No routine dose change is needed. Monitor renal function and tenofovir-related adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Tenofovir disoproxil?
MediHelp rates the interaction as minor. Berotralstat and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Berotralstat inhibits P-glycoprotein and may raise concentrations of tenofovir disoproxil, which is a P-gp substrate at the gut. The expected increase is modest.
How serious is the interaction between Berotralstat and Tenofovir disoproxil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor renal function and tenofovir-related adverse effects.
What other medicines interact with Berotralstat?
MediHelp also lists interactions of Berotralstat with, for example, Ergotamine, Nilotinib, Pimozide. The full list is on the Berotralstat page.
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